The vast majority of the creams have respond to the skin; or needless to say, consult a doctor if doubtful.
If left untreated, it could cause shooting pains, loss of muscle tone in the face, arthritis, joint swelling, meningitis, various other neurological medical problems. https://medium.com/@muscleandjointcare/the-ultimate-cbd-guide-for-muscle-and-joint-pain-2a9a373e12b6