Drug resistance is an increasing problem for the treatment of tuberculosis. The prevalence of clinical isolates with pre-existing resistance needs to be considered in any drug discovery program. Non-specific mechanisms of resistance such as increased efflux or decreased permeability need to be considered both in developing individual drug candidates and when designing novel regimens. https://www.nacrack.com/hot-choice-Open-Box-Verona-Wig-by-BelleTress-Heat-Friendly-Synthetic-Hair-Average-Cap-Buttered-Toast-R-great-buy/