Tapentadol is partly metabolized from the hepatic enzymes CYP2C9, CYP2C19, and CYP2D6 so it innately has interactions with medicine that greatly enhance or repress the action/expression of one or more of such enzymes, along with with substrates of such enzymes (due to Competitors to the enzyme); some enzyme mediators/substrates need https://ellenv197vww6.wikitron.com/user